Description 1. What Tretin is and what it is used for? TRETIN contains retinoic acid (tretinoin) as the active substance. The active ingredient of TRETIN, retinoic acid (tretinonin), when applied to the skin, stimulates the regeneration of cells belonging to the epidermis, which is the top layer of the skin, suppresses excessive keratin formation and stimulates the skin's repair mechanisms. Formulated in a special cream base that is easily accepted by the skin, TRETIN regulates the blood circulation in the skin and strengthens the skin texture by providing pores to be tightened. It also stimulates collagen production in the skin and tightens the top layer of the skin. TRETIN is in homogeneous white cream form. Thanks to these features, TRETIN shows itself in the form of various skin lesions. Used to treat acne vulgaris (acne). 2. Things to consider before using TRETIN DO NOT USE TRETIN in the following cases Do not use this medicine if you are allergic (hypersensitive) to any of the active ingredients or excipients in the formula. USE TRETIN CAREFULLY in the following cases Your doctor will decide whether to use TRETIN for you or your child in the following cases. Kız Redness and peeling occur after applying TRETIN on the skin (Depending on the severity, the drug should either be used less frequently or the drug should be interrupted for a while or the drug should be completely abandoned). Direct exposure to sunlight (During the use of TRETIN, contact with sunlight should be minimized. TRETIN should not be used until those with sunburn heal completely. If contact with ultraviolet light cannot be prevented, sunlight blocking agents should be used). Existence of eczema on the skin (TRETIN may cause irritation in areas of eczematous skin reported to be; therefore, it should be used very carefully by such patients If these warnings are valid for you at any time in the past, please consult your doctor. Using TRETIN with food and drink No interaction with food and drink has been reported. Pregnancy Consult your doctor or pharmacist before using this medication. It is not recommended to use TRETIN during pregnancy. If you notice that you are pregnant during treatment, consult your doctor or pharmacist immediately. Breast-feeding Consult your doctor or pharmacist before using this medication. It is not recommended to use TRETIN during the breastfeeding period. Driving and using machines No effects have been reported. Important about some of the ingredients of TRETIN informations Due to the butyl hydroxytoluene it contains, it may cause local skin reactions (for example, itching, redness or blisters filled with fluids such as contact dermatitis) or irritation in the eyes and subcutaneous layer. There is no need for any warning for ethanol due to its use. 2nd Concomitant use with other drugs When TRETIN is used with therapeutic soaps and cleansers, a strong drying effect occurs. Care should be taken if products containing sulfur, resorcin or salicylic acid are used in combination with TRETIN. If you are currently using any prescription or non-prescription medication, or if you have used it recently, please inform your doctor or pharmacist about them. 3. How to use TRETIN? Instructions for proper use and dose / frequency of administration: TRETIN is applied to the skin once a day at night. With the application, there may be a temporary temperature and stinging sensation on the skin. If necessary, the dose that the patient can withstand can be adjusted by interrupting treatment or reducing the frequency of administration. There may be an increase in inflamed lesions in the first weeks of treatment. This is due to the effect of the drug on the lesions and does not require discontinuation of the drug. Treatment results appear after 2-3 weeks, but more than 6 weeks may be required for full benefit. The drug can be used less frequently after the lesions start to heal. Application way and method: TRETIN should be rubbed lightly on the lesioned skin area with the fingertip. Patients using TRETIN can use cosmetics; however, the skin must be completely cleaned before treatment. Different age groups: Use in children: No data are available for children under 12 years of age. In children and adolescents over 12 years old, the adult dose is administered. Use in the elderly: Adult dose is applied to those over 65 years of age. Special use cases: Kidney / Liver failure: No dose adjustment is required. If you have an impression that the effect of TRETIN is too strong or weak, talk to your doctor or pharmacist.